SCREEN SHIELD
Myopia Management In Children*
SCREEN SHIELD®️ is an innovative myopia management nutraceutical formula developed based on the three-tier signaling pathway mechanism of myopia progression (retina-choroid-sclera). Its efficacy and mechanism target three key areas of myopia control: maintaining retinal homeostasis, enhancing choroidal blood flow, and fortifying scleral matrix collagen. This specialized formula is rich in essential eye health nutrients, including lutein (esterified form), zeaxanthin, bilberry anthocyanins, and astaxanthin from Haematococcus pluvialis.
Novel Formula to Target Three Key Ocular Tissues in Myopia Management
Protect Retina, Nourish Choroid and Strengthen Sclera
Lutein& Zeaxanthin
Protect retina by improving MPOD to filter blue light and reduce oxidative stress
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Astaxanthin
Norish choroid by increase choroidal blood flow to alleviate ocular hypoxia from near work
Blueberry Extract
Strengthen Sclera by regulating scleral remodeling via MMP2 degradation & COL1 upregulation
Scleral events critically determine eye size and thus the refractive status of the eye. Increased scleral matrix remodeling can lead to exaggerated eye growth causing myopia.
Novel Formula to Target Three Key Ocular Tissues in Myopia Management
Our proprietary mixture — SCREEN SHIELD®️ is derived from cutting-edge research on myopia, and is developed based on the retina-choroid-sclera-cascade conduction mechanism of myopia signals.
Blueberry Extract
Strengthen Sclera by regulating scleral remodeling via MMP2 degradation & COL1 upregulation [1]
Astaxanthin
Norish choroid by increase choroidal blood flow to alleviate ocular hypoxia from near work [2]
Lutein& Zeaxanthin
Protect retina by improving MPOD & BDNF to filter blue light and reduce oxidative stress [3-5]
· Scleral events critically determine eye size and thus the refractive status of the eye. Increased scleral matrix remodeling can lead to exaggerated eye growth causing myopia.
· Choroid is the main vascular tissue of the eye. Research has shown that nearwork can induce a decrease in choroidal blood flow, leading to scleral hypoxia and remodeling, ultimately resulting in axial elongation and myopia development.
· Retina is a visual “imaging” tissue that converts light signals into neural signals. It can perceive farsightedness and myopic defocus, and initiate different growth responses through distinct independent molecular mechanisms, such as dopamine (DA) and insulin.
Scientific Evidence
Exploring the Scientific Potential of SCREEN SHIELD®️ Formular
SCREEN SHIELD®️ is help children to protect eyes by targeting three key areas of myopia control:
· Maintaining retinal homeostasis；
· Enhancing choroidal blood flow；
· Fortifying scleral matrix collagen.
- 巩膜与近视的关系
巩膜是眼球最外层富含胶原纤维的“外壳”，可直接决定眼轴的长度，是近视形成的最终效应器。近视发生时巩膜发生重塑，导致巩膜胶原降解显著增多，MMP-2(质金属蛋白酶2)在胶原的降解中起着至关重要的作用。[21] - 越橘花色苷对巩膜及近视的影响
人体临床研究实证，近视儿童每日摄入 100mg 越橘精华，6 个月与 12 个月时，眼轴长度与屈光度显著减缓。[24] 动物及细胞研究显示，越橘提取物可能可以通过抑制MMP-2 与增加 I 型胶原延缓近视发展。[22-23] - AntoReal®️越橘花色苷精华
人体临床研究实证，虾青素不仅可以改善调节、舒缓视疲劳，还可以改善视网膜与脉络膜血流，从而抑制巩膜缺氧与眼轴伸长。此外，动物近视模型研究实证，虾青素可以延缓眼轴伸长与近视发展，而且有助恢复近视眼巩膜组织形态
- 脉络膜与近视的关系
脉络膜是眼部的主要血管组织，位于视网膜与巩膜之间。研究表明，近距离用眼会诱导脉络膜血流与厚度降低，并进而导致巩膜缺氧与巩膜重塑，最终导致眼轴伸长与近视发展；而增加脉络膜血流可以抑制眼轴伸长，且被认为是控制近视发展行之有效的方法。 - 虾青素对脉络膜血流及近视的影响
人体临床研究实证，虾青素不仅可以改善调节、舒缓视疲劳，还可以改善视网膜与脉络膜血流，从而抑制巩膜缺氧与眼轴伸长。此外，动物近视模型研究实证，虾青素可以延缓眼轴伸长与近视发展，而且有助恢复近视眼巩膜组织形态。 - AstaMega™️雨生红球藻虾青素微囊粉
AstaMega™️是一种源自雨生红球藻的虾青素提取物，其采用全新一代CO2超临界萃取技术，无溶液残留使用更安全；并优选搭载微囊技术的微囊型雨生红球藻微囊粉
- 视网膜与近视的关系
视网膜是光信号转化为神经信号的视觉“成像”组织，可以感知远视和近视离焦，并通过明显不同 的独立分子机制启动不同的生长反应，相关分子信号包括：多巴胺(DA)、胰岛素、视黄酸等。户外活动时间对近视的保护作用机制涉及：明亮的户外光线刺激视网膜多巴胺释放，从而抑制眼轴增长；视网膜多巴胺被认为是眼轴伸长的“停止”信号。[13-15] - 叶黄素与对视网膜及近视影响的研究
众所周知，叶黄素/脂与玉米黄质摄入可以提高视网膜黄斑色素密度(MPOD)，有助过滤蓝光并减轻蓝光诱导的视网膜氧化应激损伤。[1] 新的证据还表明，叶黄素可以提高视网膜BDNF(脑源性神经营养因子)水平[2] ，其已被实证可以靶向多巴胺能神经元并有助增加多巴胺的合成与释放[3] ，而多巴胺(DA)被认为是近视眼轴伸长的“停止”信号[4] ；因此，叶黄素可能通过BDNF-DA轴延缓近视发展，这对于近视管理具有重要意义。 - Lutemax®️专利叶黄素与玉米黄质
Lutemax®️是全球屡获殊荣的的叶黄素品牌，搭载高稳定性与高生物利用度专利技术，并具有丰富眼部健康临床与动物研究支持：
儿童临床实证，Lutemax®️可以提高MPOD(视网膜黄斑色素密度)、提高BDNF(脑源性神经营养因子)水平、改善眼睛疲劳症状及提高视觉处理速度；[5]
动物研究实证，Lutemax®️改善光诱导及高糖脂饮食的视网膜氧化应激损伤，具体机制包括提高抗氧化酶(SOD、CAT和GPX)水平、降低炎症细胞因子水平 (IL-1β、IL-6 和 TNF-α) 等。[6]
Why Lutemax®️ Lutein Esters？
Lutemax®️ is a high-quality branded lutein ingredient sourced from a fully vertically integrated supplier, provided by OmniActive, which has an established reputation for quality, safety, and efficacy for over 20 years. Lutein Esters is a from of naturally occur in marigold flowers, offering higher stability and bioavailability, unsaponified lutein. Studies show the way your body uses lutein esters is functionally better than pure lutein — with up to 62% increased bioavailability. Lutemax®️ Lutein Esters has the advantages as follow:
· Non-GMO seeds: Naturally sourced from premium marigolds cultivated with non-GMO seeds.
· Versabead Tech: Versabead is a microencapsulated beadlet technology that ensures a uniform particle size distribution and higher payloads of ingredients. The protective coating and antioxidant system protects the active ingredients and provides enhanced stability. The beadlets are easily dispersible in water or releases upon ingestion, which is an important step for nutrient absorption.
POWERFUL BY PREMIUM INGREDIENTS
Targes 3 Key Eye Tissues Related to Myopia Management
Our proprietary mixture — SCREEN SHIELD®️ is derived from cutting-edge research on myopia, and is
developed based on the retina-choroid-sclera-cascade conduction mechanism of myopia signals.
The retina is a visual “imaging” tissue that converts light signals into neural signals. It can perceive farsightedness and myopic defocus, and initiate different growth responses through distinct independent molecular mechanisms, such as dopamine (DA) and insulin. The protective mechanism of outdoor activity time on myopia involves: bright outdoor light stimulates the release of dopamine in the retina, thereby inhibiting axial growth. [13-15]
As is well known, intake of lutein and zeaxanthin can increase macular pigment density (MPOD) in the retina, help filter blue light, and alleviate blue light induced oxidative stress damage to the retina. [1] New evidence also suggests that lutein can increase the levels of BDNF (brain-derived neurotrophic factor) in the retina [2], which has been shown to target dopaminergic neurons and help increase dopamine synthesis and release [3]. Dopamine (DA) is considered a “stop” signal for myopic axial elongation [4]; Therefore, lutein may delay the development of myopia through the BDNF-DA axis, which is of great significance for myopia management.
The choroid is the main vascular tissue of the eye, located between the retina and sclera. Research has shown that close range use of the eye can induce a decrease in choroidal blood flow and thickness, leading to scleral hypoxia and remodeling, ultimately resulting in axial elongation and myopia development; Increasing choroidal blood flow can inhibit axial elongation and is considered an effective method for controlling the development of myopia.
Clinical research shows that myopia children take 100mg of blueberry essence every day, and at 6 and 12 months, the axial length and diopter of the eye are significantly reduced. Animal and cellular studies have shown that cranberry extract may delay the development of myopia by inhibiting MMP-2 and increasing type I collagen. [22-23]